Colts safety Bob Sanders, last season's NFL Defensive Player of the Year, was inactive for Sunday's game against Houston.
Sanders missed Wednesday's practice, taking a regular rest day, then participated in Thursday's workouts. But after hurting his knee, Sanders sat out again Friday. The Colts have neither disclosed which knee Sanders injured nor how extensive the injury may be.
Earlier this season, Sanders missed five games with knee and ankle injuries before returning for the Colts' last two games, victories over New England and Pittsburgh.
Houston listed three starters as inactive. Defensive tackle Amobi Okoye (high ankle sprain), linebacker Morlon Greenwood (leg) and quarterback Matt Schaub (left knee) were all out after being listed as doubtful this week.
Quarterback Sage Rosenfels replaced Schaub. Rosenfels committed three turnovers in the final five minutes of this season's first contest against Indianapolis, allowing the Colts to rally from a 17-point deficit for a 31-27 victory at Houston.
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